The IRS2 Gly1057Asp Variant Is Associated With Human Longevity
نویسندگان
چکیده
منابع مشابه
The IRS2 Gly1057Asp variant is associated with human longevity.
BACKGROUND Reduced insulin and insulin-like growth factor-1 (IGF-1) signaling extends the life span of invertebrate and mammals. Recently, reduced insulin receptor substrate-2 (IRS2) signaling was found associated with increased longevity in mice. The aim of our study was to evaluate whether a common polymorphism (Gly1057Asp) in human IRS2 gene is associated with human longevity. METHODS Six ...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 2009
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/glp154